Synthesis and pharmacological activity of 4-(2-difluoromethoxyphenyl)-1, 4-dihydropyridines

…, RO Vitolin', IP Skrastin'sh, AA Kimenis

Index: Kastron, V. V.; Dubur, G. Ya.; Vitolin', R. O.; Skrastin'sh, I. P.; Kimenis, A. A. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 5 p. 318 - 322 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 5 p. 545 - 549

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Abstract

(MRI-0.5, Nichon-Kogden, Japan) on both carotid arteries. The maximum dp/dt and electro- cardiogram were recorded on a RM-6000 polygraph (Nichon-Kogden). Test compounds were dissolved in 50% dimethylacetamlde and injected intravenously (0.05 ml/kg) through a cannule in the femoral vein. In tests on stimulated spontaneously hypertensive male rats weighing 180-220 g (Okamoto- Aoki strain) [8] aged 7-12 months the arterial systolic pressure was measured ...