Tetrahedron letters

Enantioselective synthesis of 1-deoxy-D-gulonojirimycin from a phenylglycinol-derived lactam

M Amat, M Huguet, N Llor, O Bassas, AM Gómez…

Index: Amat, Mercedes; Huguet, Marta; Llor, Nuria; Bassas, Oriol; Gomez, Antonia M.; Bosch, Joan; Badia, Josefa; Baldoma, Laura; Aguilar, Juan Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5355 - 5358

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Citation Number: 13

Abstract

Azasugars (also called iminosugars) are compounds in which the ring O-atom of a carbohydrate is replaced by nitrogen. 1 They constitute an important class of glycosidase inhibitors that are receiving a great deal of attention because of their therapeutic potential in the treatment of viral infections including HIV, 2 cancer, 3 diabetes, 4 and other metabolic disorders. 5 In particular, inhibitory activities have been reported for many naturally occurring ...