The design of efficient and selective routes to pyridyl analogues of 2, 3-dihydro-1, 4-benzodioxin-6-carbaldehyde

…, P Brown, S Dabbs, DT Davies, AJ Hennessy…

Index: Barfoot, Christopher W.; Brown, Pamela; Dabbs, Steven; Davies, David T.; Hennessy, Alan J.; Miles, Timothy J.; Pearson, Neil D. Tetrahedron Letters, 2010 , vol. 51, # 38 p. 5038 - 5040

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Citation Number: 8

Abstract

This Letter describes the synthetic routes to challenging pyridyl analogues of 2, 3-dihydro-1, 4-benzodioxin-6-carbaldehyde which were key intermediates for our antibacterial medicinal chemistry programme. All routes described started from kojic acid (8) and have been used to give multigram quantities of each aldehyde.