A one-pot procedure was developed for the synthesis of novel 3-[amino (methoxy) methylene]-2-oxo-3, 4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno [3, 4-c] pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.
