Cell 2017-07-13

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Irina Matei, Han Sang Kim, David Lyden

Index: 10.1016/j.cell.2017.06.047

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Abstract

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.