Cell Stem Cell 2017-07-06

Retinoic Acid Puts Hematopoietic Stem Cells Back To Sleep

Alexandra Rundberg Nilsson, Cornelis Jan Pronk

Index: 10.1016/j.stem.2017.06.002

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Abstract

Dormant hematopoietic stem cells (dHSCs) display superior serial reconstitution capacity compared to active HSCs, although their role in normal hematopoiesis has not been thoroughly investigated. Recently inCell, Cabezas-Wallscheid et al. (2017) demonstrate involvement of retinoic acid signaling in murine dHSCs for preservation of the HSC pool.