Cell Stem Cell 2017-07-06

Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells

Lotte Bruens, Hugo J.G. Snippert

Index: 10.1016/j.stem.2017.06.001

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Abstract

Organoid technology holds great potential for disease modeling and regenerative medicine. In this issue ofCell Stem Cell, Múnera et al. (2017) establish the generation of pluripotent stem cell-derived colon organoids that upon transplantation in mice, resembling human colon to a large extent, opening up avenues to study disease pathogenesis in human colon tissue.