Tetrahedron Letters

Ortho-selectivity in the nucleophilic aromatic substitution (SN Ar) reactions of 3-substituted, 2, 6-dichloropyridines with alkali metal alkoxides

JL Yap, K Hom, S Fletcher

Index: Tetrahedron Letters, , vol. 52, # 32 p. 4172 - 4176

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Citation Number: 9

Abstract

... Tetrahedron Letters. Volume 52, Issue 32, 10 August 2011, Pages 4172–4176. ... In this Letter, we reveal that non-polar solvents of low hydrogen bond basicities promote ortho-selective attack of 3-substituted, 2,6-dichloropyridines by alkali metal alkoxides through the formation of ...