Cell Stem Cell 2017-04-06

Of Mice and Men: Species-Specific Organoid Models of Neocortical Malformation

Jesse J. Dunnack, Joseph J. LoTurco

Index: 10.1016/j.stem.2017.03.005

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Abstract

Cellular changes underlying malformations of human cortical development may be difficult to identify with traditional mouse models. Two recent Cell Stem Cell papers, Li et al. (2017) and Bershteyn et al. (2017), use human cerebral organoids to identify specific cellular defects in neurogenesis that may explain PTEN-related macrocephaly and Miller-Dieker lissencephaly.