Cell Stem Cell 2017-04-06

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci

Evanthia E. Pashos, YoSon Park, Xiao Wang, Avanthi Raghavan, Wenli Yang, Deepti Abbey, Derek T. Peters, Juan Arbelaez, Mayda Hernandez, Nicolas Kuperwasser, Wenjun Li, Zhaorui Lian, Ying Liu, Wenjian Lv, Stacey L. Lytle-Gabbin, Dawn H. Marchadier, Peter Rogov, Jianting Shi, Katherine J. Slovik, Ioannis M. Stylianou, Li Wang, Ruilan Yan, Xiaolan Zhang, Sekar Kathiresan, Stephen A. Duncan, Tarjei S. Mikkelsen, Edward E. Morrisey, Daniel J. Rader, Christopher D. Brown, Kiran Musunuru

Index: 10.1016/j.stem.2017.03.017

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Abstract

Musunuru, Brown, Rader, and colleagues of the NHLBI NextGen consortium use multi-ethnic population cohorts of iPSCs and differentiated hepatocyte-like cells, in combination with mouse models, to discover and validate functional DNA variants and genes at blood lipid-associated loci previously identified by genome-wide association studies.