The Journal of organic chemistry

Palladium-catalyzed synthesis of 2, 3-disubstituted 5-azaindoles via heteroannulation reaction and of 2-substituted 5-azaindoles through domino Sila-Sonogashira/5- …

M Livecchi, G Calvet, F Schmidt

Index: Livecchi, Marion; Calvet, Geraldine; Schmidt, Frederic Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5006 - 5016

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Citation Number: 13

Abstract

A general and efficient procedure for the synthesis of 2, 3-disubstituted 5-azaindoles through the palladium-catalyzed heteroannulation of 4-acetamido-3-iodopyridines and diaryl-, dialkyl-, or arylalkylalkynes is described along with a study of the reaction regioselectivity. The preparation of 2-monosubstituted 5-azaindoles via sila-Sonogashira/5-endo cyclization is also reported. These methods allowed us to prepare 36 diversely substituted 5- ...