Synthese antileukämischer Indolylvinyl??1??benzofurane und??benzo [b] thiophene

…, H Char, P Fleischmann, H Fricke

Index: Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455

Full Text: HTML

Citation Number: 11

Abstract

Abstract 2-[2-(Indol-2-yl) vinyl]-1-benzofuran-und-benzo [b] thiophen-Verbindungen 6–13 und 18–22 mit endständigen Amidinium-oder Imidazolinium-Gruppen wurden synthetisiert; in ihrer antileukämischen Wirksamkeit übertreffen sie bei der Maus die isosteren 2, 2′- Vinylenbis (1-benzofuran)-und-(benzo [b] thiophen)-Verbindungen.

 Related Synthetic Route
Mercaptoacetic acid Structure

68-11-1

Mercaptoacetic acid

4-Chloro-3-formylbenzonitrile Structure

105191-41-1

4-Chloro-3-form...

~74%

Ethyl 5-cyano-1-benzothiophene-2-carboxylate Structure

105191-14-8

Ethyl 5-cyano-1...

(2-Chloro-5-nitrophenyl)methanol Structure

80866-80-4

(2-Chloro-5-nit...

~%

Ethyl 5-cyano-1-benzothiophene-2-carboxylate Structure

105191-14-8

Ethyl 5-cyano-1...

(5-Amino-2-chlorophenyl)methanol Structure

89951-56-4

(5-Amino-2-chlo...

~%

Ethyl 5-cyano-1-benzothiophene-2-carboxylate Structure

105191-14-8

Ethyl 5-cyano-1...

4-Chloro-3-(hydroxymethyl)benzonitrile Structure

105191-40-0

4-Chloro-3-(hyd...

~%

Ethyl 5-cyano-1-benzothiophene-2-carboxylate Structure

105191-14-8

Ethyl 5-cyano-1...

2,4-Dibromobenzaldehyde Structure

5629-98-1

2,4-Dibromobenz...

~%

(6-BROMOBENZO[B]THIOPHEN-2-YL)METHANOL Structure

374933-76-3

(6-BROMOBENZO[B...

6-bromobenzo[b]thiophene-2-carboxylic acid Structure

19075-58-2

6-bromobenzo[b]...

~%

(6-BROMOBENZO[B]THIOPHEN-2-YL)METHANOL Structure

374933-76-3

(6-BROMOBENZO[B...

6-Bromo-1-benzothiophene-2-carbonyl chloride Structure

105212-27-9

6-Bromo-1-benzo...

~%

(6-BROMOBENZO[B]THIOPHEN-2-YL)METHANOL Structure

374933-76-3

(6-BROMOBENZO[B...

5-(2,4-Dibrombenzyliden)-2-thioxothiazolidin-4-on Structure

105191-52-4

5-(2,4-Dibrombe...

~%

(6-BROMOBENZO[B]THIOPHEN-2-YL)METHANOL Structure

374933-76-3

(6-BROMOBENZO[B...

Ethyl 5-bromo-1H-indole-2-carboxylate Structure

16732-70-0

Ethyl 5-bromo-1...

~86%

(5-Bromo-1H-indol-2-yl)methanol Structure

53590-48-0

(5-Bromo-1H-ind...

6-bromobenzo[b]thiophene-2-carboxylic acid Structure

19075-58-2

6-bromobenzo[b]...

~95%

6-Bromo-1-benzothiophene-2-carbonyl chloride Structure

105212-27-9

6-Bromo-1-benzo...

6-Bromoindole-2-carboxylic acid Structure

16732-65-3

6-Bromoindole-2...

~79%

(6-Bromo-1H-indol-2-yl)methanol Structure

923197-75-5

(6-Bromo-1H-ind...

Ethanol Structure

64-17-5

Ethanol

6-Bromo-1-benzothiophene-2-carbonyl chloride Structure

105212-27-9

6-Bromo-1-benzo...

~71%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate Structure

105191-64-8

ethyl 6-bromobe...

2,4-Dibromobenzaldehyde Structure

5629-98-1

2,4-Dibromobenz...

~%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate Structure

105191-64-8

ethyl 6-bromobe...

6-bromobenzo[b]thiophene-2-carboxylic acid Structure

19075-58-2

6-bromobenzo[b]...

~%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate Structure

105191-64-8

ethyl 6-bromobe...

5-(2,4-Dibrombenzyliden)-2-thioxothiazolidin-4-on Structure

105191-52-4

5-(2,4-Dibrombe...

~%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate Structure

105191-64-8

ethyl 6-bromobe...

(6-Bromo-1H-indol-2-yl)methanol Structure

923197-75-5

(6-Bromo-1H-ind...

~68%

6-Bromo-1H-indole-2-carbaldehyde Structure

105191-12-6

6-Bromo-1H-indo...

(2-Chloro-5-nitrophenyl)methanol Structure

80866-80-4

(2-Chloro-5-nit...

~%

4-Chloro-3-(hydroxymethyl)benzonitrile Structure

105191-40-0

4-Chloro-3-(hyd...

Sodium cyanide Structure

143-33-9

Sodium cyanide

(5-Amino-2-chlorophenyl)methanol Structure

89951-56-4

(5-Amino-2-chlo...

~%

4-Chloro-3-(hydroxymethyl)benzonitrile Structure

105191-40-0

4-Chloro-3-(hyd...

(5-Bromo-1H-indol-2-yl)methanol Structure

53590-48-0

(5-Bromo-1H-ind...

~70%

5-Bromo-1H-indole-2-carbaldehyde Structure

53590-50-4

5-Bromo-1H-indo...

4-Chloro-3-(hydroxymethyl)benzonitrile Structure

105191-40-0

4-Chloro-3-(hyd...

~66%

4-Chloro-3-formylbenzonitrile Structure

105191-41-1

4-Chloro-3-form...

(2-Chloro-5-nitrophenyl)methanol Structure

80866-80-4

(2-Chloro-5-nit...

~%

2-(hydroxymethyl)-1-benzothiophene-5-carbonitrile Structure

105191-15-9

2-(hydroxymethy...

4-Chloro-3-formylbenzonitrile Structure

105191-41-1

4-Chloro-3-form...

~%

2-(hydroxymethyl)-1-benzothiophene-5-carbonitrile Structure

105191-15-9

2-(hydroxymethy...

(5-Amino-2-chlorophenyl)methanol Structure

89951-56-4

(5-Amino-2-chlo...

~%

2-(hydroxymethyl)-1-benzothiophene-5-carbonitrile Structure

105191-15-9

2-(hydroxymethy...

4-Chloro-3-(hydroxymethyl)benzonitrile Structure

105191-40-0

4-Chloro-3-(hyd...

~%

2-(hydroxymethyl)-1-benzothiophene-5-carbonitrile Structure

105191-15-9

2-(hydroxymethy...

Ethyl 5-cyano-1-benzothiophene-2-carboxylate Structure

105191-14-8

Ethyl 5-cyano-1...

~77%

2-(hydroxymethyl)-1-benzothiophene-5-carbonitrile Structure

105191-15-9

2-(hydroxymethy...


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