Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine

Q Yu, HW Holloway, W Luo, DK Lahiri, A Brossi…

Index: Yu, Qian-Sheng; Holloway, Harold W.; Luo, Weiming; Lahiri, Debomoy K.; Brossi, Arnold; Greig, Nigel H. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 13 p. 4687 - 4693

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Citation Number: 30

Abstract

The N-monophenylcarbamate analogues of neostigmine methyl sulfate (6) and pyridostigmine bromide (8) together with their precursors (5),(7), and the N (1)- methylammonium analogues of (−)-phenserine (12),(−)-tolserine (14),(−)-cymserine (16) and (−)-phenethylcymserine (18) were synthesized to produce long-acting peripheral inhibitors of acetylcholinesterase or butyrylcholinesterase. Evaluation of their ...