Synthesis of alkylpyrroles by the sodium borohydride reduction of acylpyrroles

R Greenhouse, C Ramirez…

Index: Greenhouse, Robert; Ramirez, Coral; Muchowski, Joseph M. Journal of Organic Chemistry, 1985 , vol. 50, # 16 p. 2961 - 2965

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Citation Number: 57

Abstract

N-Unsubstituted alkylprroles are obtained by the reduction of the corresponding acylpyrroles with sodium borohydride in boiling 2-propanol. This reaction was demonstrated to proceed via the pyrrolylalkylcarbinol and was extended to the synthesis of a branched chain alkylpyrrole 25 from the tertiary alcohol 24.