Tetrahedron

Synthesis of biaryls via cross-coupling reaction of arylboronic acids with aryl chlorides catalyzed by NiCl 2/triphenylphosphine complexes

K Inada, N Miyaura

Index: Inada, Kaoru; Miyaura, Norio Tetrahedron, 2000 , vol. 56, # 44 p. 8657 - 8660

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Citation Number: 93

Abstract

The cross-coupling reaction of tolylboronic acids (1.3 equiv.) with chloroarenes in toluene was carried out at 80–100° C in the presence of a NiCl2/PPh3 catalyst (3mol%) and K3PO4· nH2O (2.6 equiv.). The reaction can be applied to various electron-deficient and-rich chloroarenes and is economical as the industrial process.