Conformational and biological analysis of α-MSH fragment analogues with sterically constrained amino acid residues

…, WL Cody, AML Castrucci, ME Hadley

Index: Hruby, Victor J.; Cody, Wayne L.; Castrucci, Ana Maria de Lauro; Hadley, Mac E. Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 11A p. 2549 - 2573

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Citation Number: 24

Abstract

Abstract Conformational and biological analysis of the linear 4-11 fragment analogues, Ac- [Nle 4]-α-MSH 4-11-NH 2 (II) and Ac-[Nle 4, D-Phe 7]-α-MSH 4-11-NH 2 (III) and related analogues have been undertaken. In solution, the peptide backbone is flexible, but in the case of D-Phe 7 analogues an interaction of the His 6, D-Phe 7 and Arg 8 amino acid side chain groups may be present based on the shielding patterns observed in the proton NMR ...