… One??Pot Synthesis of Alkyl 2??(Dialkylamino)??4??phenylthiazole??5??carboxylates and Single??Crystal X??Ray Structure of Methyl 2??(Diisopropylamino)??4??phenylthiazole …

A Souldozi, A Ramazani, AR Dadrass…

Index: Souldozi, Ali; Ramazani, Ali; Dadrass, Ali Reza; Slepokura, Katarzyna; Lis, Tadeusz Helvetica Chimica Acta, 2012 , vol. 95, # 2 p. 339 - 348

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Citation Number: 7

Abstract

Abstract The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (= dialkyl but-2-ynedioates) in the presence of silica gel (SiO 2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5-carboxylates in fairly high yields. The structures of the products were confirmed by their IR, 1 H-and 13 C-NMR, and mass spectra, and by a single-crystal X-ray structure determination.