e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I 2 ligand
PA Coates, P Grundt, ESJ Robinson, DJ Nutt…
Index: Coates, Philippa A.; Grundt, Peter; Robinson, Emma S.J.; Nutt, David J.; Tyacke, Robin; Hudson, Alan L.; Lewis, John W.; Husbands, Stephen M. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 605 - 607
An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function.
