1-(Thienylalkyl) imidazole-2 (3H)-thiones as potent competitive inhibitors of dopamine. beta.-hydroxylase

JR McCarthy, DP Matthews, RJ Broersma…

Index: McCarthy; Matthews; Broersma; McDermott; Kastner; Hornsperger; Demeter; Weintraub; Whitten Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1866 - 1873

Full Text: HTML

Citation Number: 9

Abstract

Merrell Dow Research Institute, 2110 E. Galbraith Road, Cincinnati, Ohio 45215, Merrell Dow Research Institute, 9550 N. Zionsuille Road, Indianapolis, Indiana 46268, and Merrell Dow Research Institute, 16 rue d'dnkara, 67084 Strasbourg Cedex, France. Received October 13, I989 l-(2-Thienyla. lkyl) imidazole-2 (3Zf)-thiones (5a-k) are competitive inhibitors of dopamine 0-hydroxylase (DBH) and demonstrate the utility of thiophene in the ...