Radical cyclization of ynamides into six-or eight-membered rings. Application to the synthesis of a protoberberine analog

…, L Carro, LM Chamoreau, H Rousselière, C Courillon

Index: Balieu, Sebastien; Toutah, Krimo; Carro, Laura; Chamoreau, Lise-Marie; Rousseliere, Helene; Courillon, Christine Tetrahedron Letters, 2011 , vol. 52, # 22 p. 2876 - 2880

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Citation Number: 15

Abstract

The short and efficient synthesis of new heterocyclic compounds remains a challenging task for the synthetic organic chemists with respect to the wealth of applications in medicinal chemistry. Ynamide chemistry has received considerable attention in the last five years and has been developed by exploring many different reactivity profiles. In particular, several radical transformations of ynamides have been recently reported. 1 and 2 Among them, a radical 5-exo-dig/6- ...