Journal of medicinal chemistry

Substituted 2-Mercaptoisobutyramides and 2-Ethyl-2-mercaptobutyramides

H Lehr, LO Randall, MW Goldberg

Index: Lehr,H. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 351 - 355

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Citation Number: 1

Abstract

The synthesis of a series of S-and S-substituted 2-mercaptoisobutyramides, 2-ethy1-2- mercaptobutyramides, and the corresponding sulfones is described. The substituted 2-ethyl- 2-mercaptobutyramides were found to be more potent as central nervous system depressants than the substituted 2-mercaptoisobutyramides, which, in turn, were more potent than the sulfones. With regard to the sedative, hypnotic, and anticonvulsant activity ...

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