Cardiotonic agents. 2. Synthesis and structure-activity relationships in a new class of 6-, 7-, and 8-pyridyl-2 (1H)-quinolone derivatives

…, G Marciniak, N Decker, J Schwartz

Index: Leclerc; Marciniak; Decker; Schwartz Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2433 - 2438

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Citation Number: 24

Abstract

25 P= 6-(2 4 6-M e, l P yd P= 4-12 4 6-Me, IP ya Key: py= pyridine or 2, 4, 6- trimethylpyridine; a= SnCl,, HC1; b= EtOCH= CHCOCI; c= HZS04. is depicted in Scheme IV. The pyridyl moiety was introduced at an early stage.(Nitrophenyl) pyridyl isomers6 were purified and used as building blocks for the elaboration of the quinolone nucleus following the sequence SnCl, reduction, anilide formation, and H $04 cyclization. As expected, m- ...