Functional Analysis of an Aspartate??Based Epoxidation Catalyst with Amide??to??Alkene Peptidomimetic Catalyst Analogues

CE Jakobsche, G Peris, SJ Miller

Index: Jakobsche, Charles E.; Peris, Gorka; Miller, Scott J. Angewandte Chemie - International Edition, 2008 , vol. 47, # 35 p. 6707 - 6711

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Citation Number: 99

Abstract

The biosynthesis of natural products that contain epoxides represents a powerful stimulus for the study of epoxidase enzymes.[1] Likewise, these processes have inspired a generation of science focused on small-molecule catalysts that mediate selective epoxidations through a variety of mechanisms.[2] With respect to the naturally occurring epoxidases, the mechanistic basis of O-atom transfer is often associated with the ...