Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src

M Cushman, H Zhu, RL Geahlen…

Index: Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J. Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362

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Citation Number: 108

Abstract

A series of nitroflavones, 8a-p, and their corresponding aminoflavone hydrochloride salts, loa-p, was synthesized. The preparation of nitroflavones 8b-i, o, p began with commercially available o-hydroxyacetophenones 2b-f which were converted to o- hydroxynitroacetophenones 3a-h via a variety of nitration methods, followed by condensation with nitrobenzoyl chlorides and cyclization under acidic condition. The ...

~32%

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~91%

One??Step Reaction of Friedel–Crafts Acylation and Demethyla...

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Synthesis, structure–activity relationship of novel substitu...

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De novo synthesis of long-wavelength absorbing chlorin-13, 1...

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Serum immunoreactive-leptin concentrations in normal-weight ...

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