Copper (II) bromide as an efficient catalyst for the selective protection and deprotection of alcohols as bis (4-methoxyphenyl) methyl ethers

…, YA Dembelé, Y Bikard, JM Weibel, A Blanc, P Pale

Index: Mezaache, Rofia; Dembele, Yenimegue Albert; Bikard, Yann; Weibel, Jean-Marc; Blanc, Aurelien; Pale, Patrick Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7322 - 7326

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Citation Number: 21

Abstract

In a cheap and eco-friendly process, primary and secondary alcohols were easily protected as bis (methoxyphenyl) methyl (BMPM) ethers in good yields using CuBr2 as a catalyst in acetonitrile at room temperature. Deprotection could easily be achieved using the same catalyst but in ethanol. Both Cu-catalyzed protection and deprotection were orthogonal to other methods and fully compatible with other functional groups.