e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
… conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D- …
AL Choy, JVNV Prasad, FE Boyer, MD Huband…
Index: Choy, Allison L.; Vara Prasad; Boyer, Frederick E.; Huband, Michael D.; Dermyer, Michael R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4699 - 4702
A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. Certain amino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.
