Characterization of the East Asian variant of aldehyde dehydrogenase-2 bioactivation of nitroglycerin and effects of Alda-1

…, M Russwurm, D Koesling, K Schmidt, B Mayer

Index: Beretta, Matteo; Gorren, Antonius C.F.; Wenzl, M. Verena; Weis, Robert; Russwurm, Michael; Koesling, Doris; Schmidt, Kurt; Mayer, Bernd Journal of Biological Chemistry, 2010 , vol. 285, # 2 p. 943 - 952

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Citation Number: 31

Abstract

Abstract The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase, and nitroglycerin (GTN) denitrating activities. The small molecule Alda-1 was reported to partly restore low acetaldehyde dehydrogenase activity of this variant. In the present study we compared the wild type enzyme (ALDH2* 1) with the Asian variant (ALDH2* 2) regarding GTN bioactivation and ...