Demethylation of crown ethers, aza crown ethers, and cryptands which have inward??facing anisole units by lithium aluminum hydride in tetrahydrofuran

…, JL Hallman, JB Phillips, RA Bartsch

Index: Czech, Anna; Czech, Bronislaw P.; Desai, Dhimant H.; Hallman, Johnny L.; Phillips, John B.; Bartsch, Richard A. Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1355 - 1358

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Citation Number: 8

Abstract

Methods for the protection of inward-facing phenolic groups in macrocyclic polyether compounds have recently received considerable attention. Methoxymethyl [ 11, methyl [2], ally1 [3], and acetyl [4] groups have been utiliz- ed for protection of phenolic functions during ring- forming reactions. Subsequent deprotection has been ac- complished under a variety of conditions. Particularly ef- fective is the use of anhydrous lithium iodide in pyridine for demethylation of methyl- ...