Antimalarial phenanthrene amino alcohols. 2. Trifluoromethyl-containing 9-phenanthrenemethanols

EA Nodiff, AJ Saggiomo, M Shinbo…

Index: Nodiff,E.A. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 775 - 780

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Citation Number: 12

Abstract

LiAlH,. The mixt was stirred at room temp for 29 hr. The reaction was hydrolyzed with H,O and extracted with Et,O. The Et,O soln was evapd in vacuo to yield 3.0 g of crude product. Tlc showed a number of spots (silica gel-C,H,). The crude reaction product was chromatographed on a 28 X 3 cm column of silica gel (C,H, elution, 60-ml fractions). Fractions 6-12 gave 500 mg of the starting amino ketone (15%) (nmr, ir). Fractions 22-29 (10% Et,O) gave 500 mg of product ...