Abstract A new series of 3-acetyl-2-aryl-2H/methyl-5-[3-(6-methylpyridinyl)]-2, 3-dihydro-[1, 3, 4]-oxadiazole derivatives were synthesized from 6-methyl nicotinate through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1 H NMR, 13 C NMR and mass spectral data. Three dimensional structure of the compound 5f was further confirmed by single crystal X-ray ...