Synthesis of 1, 2-(2-dimethylaminomethyl-1-oxopolymethylene) benzenes and their 4, 5-diethoxy derivatives and their anti-inflammatory activity

VK Daukshas, PG Gaidyalis, LK Labanauskas…

Index: Daukshas, V. K.; Gaidyalis, P. G.; Labanauskas, L. K.; Gumbaragite, L. F.; Gasperavichene, G. A. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 8 p. 544 - 547 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 8 p. 32 - 34

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Citation Number: 2

Abstract

Certain derivatives of 3-dimethylaminopropionylbenzene exhibit anti-inflammatory activity (AA) and are slightly toxic [2, 3]. Therefore, in order to study the relationship between the chemical structure and the AA, and also to search for new drugs, we synthesized and studied the cyclic analogs of these compounds (IIa-f), which were previously unknown or had not been examined for AA.