Synthesis of 4??Arylpiperazine Derivatives of Moclobemide: Potential Antidepressants with a Dual Mode of Action

…, R Araya??Maturana, JK Cárcamo…

Index: Pessoa-Mahana, Hernan; Gajardo, Gonzalo Recabarren; Araya-Maturana, Ramiro; Carcamo, Johann Kosche; Pessoa-Mahana, C. David Synthetic Communications, 2004 , vol. 34, # 14 p. 2513 - 2521

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Citation Number: 11

Abstract

Abstract We report here the synthesis of substituted 4??chloro??N??[3??oxo??3??(4??aryl??1?? piperazinyl)??propyl] benzamides (5–9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual pharmacological profile: MAO??A inhibitor and 5??HT1A receptor affinity.