Structure–Activity Relationship and Pharmacokinetic Studies of 1, 5-Diheteroarylpenta-1, 4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents

R Wang, C Chen, X Zhang, C Zhang…

Index: Cao, Bin; Wang, Yong; Ding, Kan; Neamati, Nouri; Long, Ya-Qiu Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1239 - 1245

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Citation Number: 11

Abstract

Forty-three 1, 5-diheteroaryl-1, 4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen- containing aromatic rings. They were synthesized using a Horner–Wadsworth–Emmons