Exploration of L-proline-catalyzed α-aminoxylation of aldehyde to (S)-guaifenesin-related drug molecules

SP Panchgalle, SS Kunte, SP Chavan…

Index: Panchgalle, Sharad P.; Kunte, Sunita S.; Chavan, Subhash P.; Kalkote, Uttam R. Synthetic Communications, 2011 , vol. 41, # 13 p. 1938 - 1946

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Abstract

Guaifenesin 1 was extracted from plants of the Guiacum genus native to tropical and subtropical American regions. It has been used in treatment of cough, [1a] gout, [1b] fibromyalgia, [1c] and primary dysmenorrhea. [1d] Nowadays, many guaifenesin derivatives [ 2 2. Asymmetris synthesis of guaifenesin and its derivatives: (a) Nelson , WL ; Wennerstrom , JE ; Sankar , SR Absolute configuration of glycerol derivatives. 3. Synthesis and Cupra A circular dichroism spectra ...