Synthesis of the ultimate hepatocarcinogen, 2-acetylaminofluorene N-sulphate

FA Beland, DW Miller, RK Mitchum

Index: Beland, Frederick A.; Miller, Dwight W.; Mitchum, Ronald K. Journal of the Chemical Society, Chemical Communications, 1983 , # 1 p. 30 - 31

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Citation Number: 14

Abstract

Reaction of N- hydroxy-2-acetylaminofluorene with dicyclohexylcarbodi-imide and H,SO, yields 2-acetylaminofluorene N-sulphate, the presumed ultimate form of the hepatocarcinogen 2-acetylamino- f I uorene. ... N-oxidation and O-esterification.lP2 A specific ester, 2- ... AAF N-sulphate, has been implicated in the carcinogenic ... To N-hydroxy-2-AAF (1) (100 mg) were added a 5-fold ... Published on 01 January 1983. Downloaded by google on 15/02/2016 ...