Tetrahedron

Regioselective 4-amino-de-chlorination of trichloro-and dichloro-pyrimidines with N-sodium carbamates

…, E Corradi, G Dettori, C Mioskowski, A Volonterio…

Index: Montebugnoli, Dario; Bravo, Pierfrancesco; Corradi, Eleonora; Dettori, Giovanna; Mioskowski, Charles; Volonterio, Alessandro; Wagner, Alain; Zanda, Matteo Tetrahedron, 2002 , vol. 58, # 11 p. 2147 - 2153

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Citation Number: 14

Abstract

4-N-Alkoxycarbonylamino-2, 6-dichloro-and-2-chloro-pyrimidines have been synthesized in good to excellent regioselectivity and yields from N-sodium carbamates and, respectively, 2, 4, 6-trichloropyrimidine and 2, 4-dichloropyrimidine, in DMF, rt, 15–30min. The reaction is effective also with 4, 6-dichloropyrimidine, producing 4-N-alkoxycarbonylamino-6- chloropyrimidines in good yields. Some conformational features of 4-N- ...