Synthesis and pharmacological activity of 3H-[1, 4] diazepino-[2, 3-g] indoles

…, YG Bundel', MS Luk'yanova, VM Kurilenko

Index: Chetverikov, V. P.; Titov, G. A.; Bundel' Yu. G.; Luk'yanova, M. S.; Kurilenko, V. M. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 12 p. 874 - 878 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 12 p. 1461 - 1465

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Citation Number: 2

Abstract

Hypotensives, antispasmodics, tranquilizers, and antitumor agents have been found among the pyrrolo-and indolobenzdiazepines [5, 7-9]. The diazepine ring in these compounds is directly coupled to the pyrrole ring. In an earlier studies [i, 6] we reacted l-acetyl-5, 6- diaminoindoline (I) with acetoacetic ester to obtain tetrahydrodiazepino [2, 3-f] indole (II) which appeared to be a potential pharmacologically active substance within whose ...