Organic letters

Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO

H Baars, A Beyer, SV Kohlhepp, C Bolm

Index: Baars, Hannah; Beyer, Astrid; Kohlhepp, Stefanie V.; Bolm, Carsten Organic Letters, 2014 , vol. 16, # 2 p. 536 - 539

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Citation Number: 31

Abstract

Benzimidazoles can reveal important bioactivities,(4) and several strategies for their synthesis have been developed. Commonly, they are prepared from 1,2-diaminoarenes by condensations with carboxylic acids under harsh dehydrating conditions(5) or oxidative couplings with aldehydes.(6) Under milder reaction conditions benzimidazoles can be accessed from amidines by metal-catalyzed intramolecular C–N cross-couplings.(7) Considering our previous ...