Synthesis and biological activities of [E]-5-(2-acylvinyl) uracils

…, SK Dasgupta, LN Chaudhuri, JS Mahanty…

Index: Kundu; Dasgupta; Chaudhuri; Mahanty; Spears; Shahinian European Journal of Medicinal Chemistry, 1993 , vol. 28, # 6 p. 473 - 479

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Citation Number: 26

Abstract

Abstract The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl) uracils 8a– 8g is described. These compounds were found to have cytotoxic activities against CCRF- CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.

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