Synthesis

Synthesis of Tetrasubstituted NH Pyrroles and Polysubstituted Furans via an Addition and Cyclization Strategy

L Li, MN Zhao, ZH Ren, J Li, ZH Guan

Index: Li, Liang; Zhao, Mi-Na; Ren, Zhi-Hui; Li, Jianli; Guan, Zheng-Hui Synthesis, 2012 , vol. 44, # 4 p. 532 - 540

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Abstract

Abstract The FeCl 3-catalyzed addition and cyclization of enamino esters with nitroolefins provides a straightforward and general method for the synthesis of tetrasubstituted NH pyrroles. This novel method tolerates a wide range of functionality, and allows for rapid elaboration of the nitroolefins into a variety of substituted pyrroles in good yields. Further, an efficient KOAc-promoted addition and cyclization protocol toward substituted furans has ...