Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives

NA Shakil, MK Singh, M Sathiyendiran, J Kumar…

Index: Shakil; Singh, Manish K.; Sathiyendiran; Kumar; Padaria, Jasdeep C. European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 120 - 131

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Citation Number: 31

Abstract

Novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives were synthesized and characterized by using spectral techniques like IR, 1H NMR, 13C NMR, COSY, DEPT, and GC-MS. All these compounds were screened for anti-fungal, anti- bacterial and anti-oxidant activity. Cyclohexenone derivatives, in general, showed better anti- fungal and anti-bacterial activity than parent chalcones. Whereas, all the Indazole ...