Tetrahedron letters

Stereospecific synthesis of 4-carboxyphenylalanine and derivatives for use in Fmoc-based solid-phase peptide synthesis

W Wang, NU Obeyesekere, JS McMurray

Index: Wang, Wei; Obeyesekere, Nihal U.; McMurray, John S. Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6661 - 6664

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Citation Number: 11

Abstract

Starting from Nα-benzyloxycarbonyl-L-tyrosine (O-triflate) benzyl ester, we have prepared enantiomerically pure 4-carboxyphenylalanine and 4-methoxycarbonylphenylalanine derivatives using palladium (0) catalyzed carbonylation reactions. These unnatural amino acids were suitably protected and were used in solid-phase peptide synthesis using the Fmoc/t-butyl approach.