Tetrahedron letters

Preparation of 2, 3-dihydro-1H-spiro [isoquinoline-4, 4′-piperidine] via an N-sulfonyl Pictet–Spengler reaction

J Liu, T Jian, I Sebhat, R Nargund

Index: Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117

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Citation Number: 4

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A high yielding synthesis of variously substituted 2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine] is reported. N-(2-nitrophenyl)sulfonyl was successfully used as both an activating and protecting group for the key Pictet–Spengler reaction. ... The privileged structure 1-(methylsulfonyl)- ...