Cytochrome P-450 complex formation in the metabolism of phenylalkylamines. 8. Stereoselectivity in metabolic intermediary complex formation with a series of chiral 2 …

UB Paulsen-Soerman, KH Joensson…

Index: Paulsen-Soerman, Ulla B.; Joensson, Karl-Henrik; Lindeke, Bjoern G. A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 342 - 346

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Citation Number: 15

Abstract

The formation of cytochrome P-450 metabolic intermediary (MI) complexes from the enantiomers of four 2-al-kyl-substituted 1-phenyl-2-aminoethanes was investigated during reduced nicotinamide adenine dinucleotide phosphate (NADPH) dependent metabolism in liver microsomes from phenobarbital-pretreated rats. The 2-alkyl substituents were methyl (amphetamine), ethyl, n-propyl, and n-butyl groups. The chiral amines were prepared from ...