Pharmacokinetics and metabolism of selective oxoeicosanoid (OXE) receptor antagonists and their effects on 5-oxo-6, 8, 11, 14-eicosatetraenoic acid (5-oxo-ETE)- …

C Cossette, S Chourey, Q Ye…

Index: Gore, Vivek; Gravel, Sylvie; Cossette, Chantal; Patel, Pranav; Chourey, Shishir; Ye, Qiuji; Rokach, Joshua; Powell, William S. Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 364 - 377

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Abstract

The potent eosinophil chemoattractant 5-oxo-6, 8, 11, 14-eicosatetraenoic acid (5-oxo-ETE) is a 5-lipoxygenase product that acts via the selective OXE receptor, which is present in many species, but not rodents. We previously reported that the indole 230 is a potent human OXE receptor antagonist. The objective of the present study was to determine whether the monkey would be a suitable animal model to investigate its pharmaceutical potential. We ...