Rapid Development and Scale-Up of a 1 H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

…, EF Plocharczyk, GA Rener, RN Richey…

Index: May, Scott A.; Johnson, Martin D.; Braden, Timothy M.; Calvin, Joel R.; Haeberle, Brian D.; Jines, Amy R.; Miller, Richard D.; Plocharczyk, Edward F.; Rener, Gregory A.; Richey, Rachel N.; Schmid, Christopher R.; Vaid, Radhe K.; Yu, Hannah Organic Process Research and Development, 2012 , vol. 16, # 5 p. 982 - 1002

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Citation Number: 20

Abstract

The development of reactions in a continuous fashion in plug flow tube reactors (PFR) offers unique advantages to the drug development and scale-up process and can also enable chemistry that would be difficult to perform via batch processing. Herein, we report the development of two different continuous flow approaches to a key 1 H-4-substituted imidazole intermediate (5). In a first generation approach, rapid optimization and scale-up ...