Tetrahedron

A novel synthesis of pyrrolo [1, 2-d][1, 4] diazocines from tetrahydropyrrolo [1, 2-a] pyrazines using activated alkynes in pyrazine ring expansion

…, AV Listratova, RS Borisov, LN Kulikova, AV Varlamov

Index: Voskressensky, Leonid G.; Titov, Alexander A.; Borisova, Tatiana N.; Listratova, Anna V.; Borisov, Roman S.; Kulikova, Larisa N.; Varlamov, Alexey V. Tetrahedron, 2010 , vol. 66, # 27-28 p. 5140 - 5148

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Citation Number: 8

Abstract

The few pathways towards benzoannulated pyrrolodiazocines include Ugi-type reaction and Dieckman condensation 4 of adequately substituted pyrroles and a multi-step synthesis of fully hydrogenated pyrrolo[1,2-a][1,4]diazocines and pyrrolo[1,2-a][1,5]diazocines starting from proline and pyroglutamic acid. 5 It was shown that pyrrolo[1,2-a][1,4]diazocines could be used as dipeptide reverse-turn mimetics 6 exhibiting cognition enhancing activity. ... We have previously ...