Syntheses of Benzo [b] furan-6-carbonitrile and 6-Cyanobenzo [b] furan-2-boronic Acid Pinacol Ester

JD Williams, X Ding, S Nguyen, KK Vines…

Index: Williams, John D.; Ding, Xiaoyuan; Nguyen, Son; Vines, Kimberly K.; Peet, Norton P. Synthetic Communications, 2013 , vol. 43, # 14 p. 1974 - 1979

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Abstract

6-Cyanobenzo[b]furan-2-boronic acid pinacol ester (10) is a potentially useful two-point scaffold for the construction of specific compounds or compound libraries with benzofuran cores. Using a per-iodination/de-iodination strategy coupled with Sonogashira alkynylation and Cu-catalyzed heteroannulation, we have developed a procedure that allows the preparation of benzo[b]furan-6-carbonitrile (9) and 6-cyanobenzo[b]furan-2-boronic acid pinacol ester ...