... at which time HPLC/MS indicated that the pyrrole 8 was converted to the pyrrolopyrimidinone 1. The reaction mixture was diluted with 1.5 L water, heated at 60 °C for 1 h, and then concentrated to small volume (∼1.5 L ... (f) Foloppe, N.; Fisher, LM; Howes, R.; Kierstan, P.; Potter, A ...