Journal of Fluorine Chemistry

A synthetic approach to seven-membered lactones by the microbial transformation of ynones having a trifluoromethyl group

T Kitazume, T Sato

Index: Kitazume,T.; Sato,T. Journal of Fluorine Chemistry, 1985 , vol. 30, p. 189

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Citation Number: 21

Abstract

Abstract Studies on the microbial transformations of a number of ynones bearing a trifluoromethyl group prepared by the reaction of ethyl trifluoroacetate with a variety of lithium alkynates, have been undertaken. The major products were the corresponding carbinols but microbial carbon-carbon bond degradation and formation occurred also, which proceeded to novel fluorinated seven-membered lactones as significant products.